Журнал «Медицина неотложных состояний» Том 22, №3, 2026

Актуальність. Дослідження включало визначення рівнів деяких параметрів та антиоксидантів у сироватці крові пацієнтів з ішемічною хворобою серця (ІХС) порівняно зі здоровими людьми з метою з’ясування кореляції між цими змінами. Вимірювані параметри включають: малоновий діальдегід (MDA), глутатіон (GSH), вітамін С, сечову кислоту, загальний білок, альбумін, глобулін і деякі мікроелементи (хром (Cr) та селен (Se)). Матеріали та методи. Сироваткові рівні MDA, GSH, вітаміну С, сечової кислоти, загального білка, альбуміну, глобуліну, Cr і Se вимірювали у 100 пацієнтів з ІХС (50 чоловіків, 50 жінок) та 100 умовно здорових осіб (50 чоловіків, 50 жінок). Результати. Статистичний аналіз даних виявив значне підвищення вмісту MDA і сечової кислоти в сироватці крові пацієнтів з ІХС порівняно з контрольною групою. Дослідження також показало суттєве зниження рівнів GSH, Cr та Se в сироватці крові пацієнтів проти контрольної групи і для обох статей. З іншого боку, спостерігалося значне зниження концентрацій вітаміну С, загального білка, альбуміну, тоді як суттєвих відмінностей у рівні глобуліну між пацієнтами та контрольною групою (для обох статей) не виявлено. Висновки. Не було виявлено впливу статі на досліджувані показники, за винятком сечової кислоти.

Background. The study included determination of the levels of some parameters and antioxidants in serum of patients with coronary artery disease (CAD) compared to healthy people aiming at clarifying the relation among these changes. The measured parameters include: malondialdehyde (MDA), glutathione (GSH), vitamin C, uric acid, total protein, albumin, globulin and some trace elements (chromium (Cr) and selenium (Se)). Materials and methods. Serum MDA, GSH, vitamin C, uric acid, total protein, albumin, globulin, Cr and Se were measured in 100 CAD patients (50 male, 50 female) and 100 supposedly healthy subjects (50 male, 50 female). Results. Statistical data analysis revealed a significant elevation in the serum levels of MDA and uric acid in patients with CAD compared to control group. The study also showed a significant decrease in the levels of GSH, Cr and Se in serum of patients as compared to control group and for both sexes. On the other hand, a significant decrease was observed in vitamin C, total protein, albumin, with no significant differences in serum globulin in patients versus control group and for both sexes. Conclusions. There was no effect of sex on the studied parameters except uric acid.

ішемічна хвороба серця; малоновий діальдегід; вітамін С; глутатіон; хром; селен

coronary artery disease; malondialdehyde; vitamin C; glutathione; chromium; selenium

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