Інформація призначена тільки для фахівців сфери охорони здоров'я, осіб,
які мають вищу або середню спеціальну медичну освіту.


Підтвердіть, що Ви є фахівцем у сфері охорони здоров'я.

 

"Kidneys" Том 8, №1, 2019

Back to issue

Thyroid dysfunction and kidney diseases

Authors: Мельник А.А.
Медицинская компания «Empirica», г. Киев, Украина

Categories: Nephrology

Sections: Specialist manual

print version


Summary

Гормони щитоподібної залози (ЩЗ) необхідні для нормального функціонування нирок, що, у свою чергу, є не тільки органом для метаболізму і виведення гормонів ЩЗ, але й мішенню для дії деяких тиреоїдних гормонів. Гіпотиреоз і гіпертиреоз пов’язані з клінічно значущими змінами в діяльності нирок. Гіпотиреоз супроводжується зниженням швидкості клубочкової фільтрації (ШКФ), гіпонатріємією та зміною здатності нирок до виведення води із організму. Підвищені рівні гормонів ЩЗ призводять до збільшення ШКФ і ниркового кровотоку. Ниркова недостатність впливає на функцію ЩЗ. Хронічна хвороба нирок супроводжується помітними ефектами на осі гіпоталамус — гіпофіз — щитоподібна залоза. Є зв’язок між раком ЩЗ і пухлинами нирок. Дані останніх досліджень показують, що гормони ЩЗ, особливо Т3, можна розглядати як маркер виживання у пацієнтів із захворюванням нирок.

Гормоны щитовидной железы (ЩЖ) необходимы для нормального функционирования почек, которые, в свою очередь, являются не только органом для метаболизма и выведения гормонов ЩЖ, но и служат мишенью для действия некоторых тиреоидных гормонов. Гипотиреоз и гипертиреоз связаны с клинически значимыми изменениями в деятельности почек. Гипотиреоз сопровождается снижением скорости клубочковой фильтрации (СКФ), гипонатриемией и изменением способности почек выводить воду из организма. Повышенные уровни гормонов ЩЖ приводят к увеличению СКФ и почечного кровотока. Почечная недостаточность влияет на функцию ЩЖ. Хроническая болезнь почек сопровождается заметными эффектами на оси гипоталамус — гипофиз — щитовидная железа. Имеется связь между раком ЩЖ и опухолями почек. Данные последних исследований показывают, что гормоны ЩЖ, особенно Т3, можно рассматривать как маркер выживания у пациентов с заболеванием почек.

Thyroid hormones provide normal functioning of the kidneys, which in turn are not only an organ for the metabolism and excretion of thyroid hormones but also serve as targets for the action of certain thyroid hormones. Hypothyroidism and hyperthyroidism are associated with clinically significant changes in the activity of the kidneys. Hypothyroidism is accompanied by a decrease in glomerular filtration rate (GFR), hyponatremia and a change in the ability to excrete water from the body through the kidney. Elevated levels of thyroid hormones lead to an increase in GFR and renal blood flow. Renal failure affects thyroid function. Chronic kidney disease is accompanied by noticeable effects on the hypothalamus-pituitary-thyroid axis. There is a link between thyroid cancer and kidney tumors. Recent studies show that thyroid hormones, especially T3, can be considered as a marker of survival in patients with kidney disease.


Keywords

дисфункція щитоподібної залози; гіпотиреоз; гіпертиреоз; хронічна хвороба нирок; пошкодження нирок

дисфункция щитовидной железы; гипотиреоз; гипертиреоз; хроническая болезнь почек; повреждения почек

thyroid dysfunction; hypothyroidism; hyperthyroidism; chronic kidney disease; kidney failure


For the full article you need to subscribe to the magazine.


Bibliography

1. Feinstein E.I., Kaptein E.M., Nicoloff J.T., Massry S.G. Thyroid function in patients with nephrotic syndrome and normal renal function // American Journal of Nephrology. 1982; 2: 70-76. doi: org/10.1159/000166587.

2. Kaptein E.M. Thyroid function in renal failure // Contributions to Nephrology. 1986; 50: 64-72.

3. Fonseca T.L., Correa-Medina M., Campos M.P. et al. Coordination of hypothalamic and pituitary T3 production regulates TSH expression // J. Clin. Invest. 2013; 123: 1492-1500. doi: 10.1172/ICI61231.

4. Gereben B., Zavacki A.M., Ribich S. et al. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling // Endocr. Rev. 2008; 29: 898-938. doi: 10.1210/er.2008-0019.

5. Bianco A.C., Salvatore D., Gereben B. et al. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases // Endocr. Rev. 2002; 23: 38-89. doi: 10.1210/edrv.23.1.0455.

6. Braunlich H. Thyroid hormones influencing renal electrolyte excretion in saline loaded rats of different ages // Physiologia Bohemoslovaca. 1984; 33: 303-308.

7. Gattineni J., Sas D., Dagan A., Dwarakanath V., Baum M.G. Effect of thyroid hormone on the postnatal renal expression of NHE8 // American Journal of Physiology. Renal. Physio–logy. 2008; 294: F198-F204. doi: 10.1152/aiprenal.00332.2007.

8. Katyare S.S., Modi H.R., Patel S.P., Patel M.A. Thyroid hormoneinduced alterations in membrane structure-function relationships: studies on kinetic properties of rat kidney microsomal Na(C),K (C)-ATPase and lipid/phospholipid profiles // Journal of Membrane Biology. 2007; 219: 71-81. doi: 10.1007/s00232-007-9063-7.

9. Capasso G., De Tommaso G., Pica A., Anastasio P., Capasso J., Kinne R., De Santo N.G. Effects of thyroid hormones on heart and kidney functions // Mineral and Electrolyte Metabolism. 1999; 25: 56-64. doi: 10.1159/000057421.

10. Iglesias P., Bajo M.A., Selgas R., Díez J.J. Thyroid dysfunction and kidney disease: An update // Rev. Endocr. Metab. Disord. 2016. dоi: 10.1007/s11154-016-9395-7.

11. Crowley W.F. Jr, Ridgway E.C., Bough E.W., Francis G.S., Daniels G.H., Kourides I.A. et al. Noninvasive evaluation of cardiac function in hypothyroidism.Response to gradual thyroxine replacement // N. Engl. J. Med. 1977; 296: 1-6. doi: 10.1056/NEJM197701062960101.

12. Diekman M.J., Harms M.P., Endert E., Wieling W., Wiersinga W.M. Endocrine factors related to changes in total periphe–ral vascular resistance after treatment of thyrotoxic and hypothyroid patients // Eur. J. Endocrinol. 2001; 144: 339-46.

13. Klein I., Ojamaa K. Thyroid hormone and the cardiovascular system // N. Engl. J. Med. 2001; 344: 501-9. doi: 10.1056/NEJM200102153440707.

14. Schmid C., Brandle M., Zwimpfer C., Zapf J., Wiesli P. Effect of thyroxine replacement on creatinine, insulin-like growth factor 1, acid-labile subunit, and vascular endothelial growth factor // Clin. Chem. 2004; 50: 228-31.

15. Bradley S.E., Coelho J.B., Sealey J.E., Edwards K.D., Stephan F. Changes in glomerulotubular dimensions, single nephron glomerular filtration rates and the renin-angiotensin system in hypothyroid rats // Life Sci. 1982; 30: 633-9.

16. Montenegro J., Gonzalez O., Saracho R., Aguirre R., Martinez I. Changes in renal function in primary hypothyroi–dism // Am. J. Kidney Dis. 1996; 27: 195-8.

17. Vargas F., Moreno J.M., Rodriguez-Gomez I., Wangensteen R., Osuna A., Alvarez-Guerra M. et al. Vascular and renal function in experimental thyroid disorders // Eur. J. Endocrinol. 2006; 154: 197-212. doi: 10.1530/eje.1.02.093.

18. Van Hoek, I., Daminet, S. Interactions between thyroid and kidney function in pathological conditions of these organ systems: a review // Gen. Comp. Endocrinol. 2009; 3: 205-215. doi: 10.1016/j.ygcen.2008.12.008.

19. Zimmerman R.S., Ryan J., Edwards B.S., Klee G., Zimmerman D., Scott N. et al. Cardiorenal endocrine dynamics du–ring volume expansion in hypothyroid dogs // Am. J. Physiol. 1988; 255: R61-6.

20. Garg L.C., Tisher C.C. Effects of thyroid hormone on Na-K-adenosine triphosphatase activity along the rat nephron // J. Lab. Clin. Med. 1985; 106: 568-72.

21. Suher M., Koc E., Ata N., Ensari C. Relation of thyroid disfunction, thyroid autoantibodies, and renal function // Ren. Fail. 2005; 27: 739-42.

22. Den Hollander J.G., Wulkan R.W., Mantel M.J., Berghout A. Correlation between severity of thyroid dysfunction and renal function // Clin. Endocrinol. (Oxf) 2005; 62: 423-7. doi: 10.1111/j.1365-2265.2005.02236.x.

23. Quesada A., Sainz J., Wangensteen R., Rodriguez-Gomez I., Vargas F., Osuna A. Nitric oxide synthase activity in hyperthyroid and hypothyroid rats // Eur. J. Endocrinol. 2002; 147: 117-22.

24. Singh G., Sharma A.C., Thompson E.B., Gulati A. Renal endothelin mechanism in altered thyroid states // Life Sci. 1994; 54: 1901-8.

25. Haro J.M., Sabio J.M., Vargas F. Renal beta-adrenoceptors in thyroxine-treated rats // J. Endocrinol. Invest. 1992; 15: 605-8.

26. Asmah B.J., Wan Nazaimoon W.M., Norazmi K., Tan T.T., Khalid B.A. Plasma renin and aldosterone in thyroid diseases // Horm. Metab. Res. 1997; 29: 580-3. doi: 10.1055/s-2007-979105.

27. Kobori H., Ichihara A., Miyashita Y., Hayashi M., Saruta T. Mechanism of hyperthyroidism-induced renal hypertrophy in rats // J. Endocrinol. 1998; 159: 9-14.

28. Manetti L., Pardini E., Genovesi M., Campomori A., Grasso L., Morselli L.L. et al. Thyroid function differently affects serum cystatin C and creatinine concentrations // J. Endocrinol. Invest. 2005; 28: 346-9.

29. Nakamura S., Ishiyama M., Kosaka J., Mutoh J., Umemura N., Harase C. Urinary N-acetyl-beta-D-glucosamini–dase (NAG) activity in patients with Graves’ disease, subacute thyroiditis, and silent thyroiditis: A longitudinal study // Endocrinol. Jpn. 1991; 38: 303-8.

30. Basu G., Mohapatra A. Interaction between thyroid di–sordes and kidney disease // Indian J. Endocrinol. Metab. 2012 Mar-Apr; 16(2): 204-213. doi: 10.4103/2230-8210.93737.

31. Lim V.S., Fang V.S., Katz F.I., Refetoff S. Thyroid dysfunction in chronic renal failure. A study of the pituitary thyroid axis and peripheral turnover kinetics of thyroxine and Triiodothyronine // Journal of Clinical Investigation. 1977; Vol. 60, № 3: 522-534. doi: 10.1172/JCI108804.

32. Zoccali С., Mallamaci F., Tripepi G., Cutrupi S., P. Pizzini P. Low triiodothyronine and survival in end-stage renal di–sease // Kidney International. 2006; Vol. 70, № 3: 523-528. doi: org/10.1038/sj.ki.5001566.

33. Hegedus L., Andersen J.R., Poulsen L.R., Perrild H., Holm B., Gundtoft E., Hansen J.M. Thyroid gland volume and serum concentrations of thyroid hormones in chronic renal failure // Nephron. 1985; 40: 171-174. doi: 10.1159/000183455.

34. Miki H., Oshimo K., Inoue H., Kawano M., Morimoto T., Monden Y., Yamamoto Y., Kita S. Thyroid carcinoma in patients with secondary hyperparathyroidism // Journal of Surgical Oncology. 1992; 49: 168-171.

35. Kaptein E.M., Levitan D., Feinstein E.I., Nicoloff J.T., Massry S.G. Alterations of thyroid hormone indices in acute renal failure and in acute critical illness with and without acute renal failure // American Journal of Nephrology. 1981; 1: 138-143. doi: 10.1159/000166531.

36. Bernet V.J. Reversible renal insufficiency attributable to thyroid hormone withdrawal in a patient with type 2 diabetes mellitus // Endocrine Practice. 2004; 10: 339-344. doi: org/10.4158/EP.10.4.339.

37. Kursat S., Alici T., Colak H.B. A case of rhabdomyolysis induced acute renal failure secondary to statin-fibrate-derivative combination and occult hypothyroidism // Clinical Nephrology. 2005; 64: 391-393.

38. Birewar S., Oppenheimer M., Zawada E.T. Jr. Hypothyroid acute renal failure // South Dakota Journal of Medicine. 2004; 57: 109-110.

39. Kar P.M., Hirani A., Allen M.J. Acute renal failure in a hypothyroid patient with rhabdomyolysis // Clinical Nephrology. 2003; 60: 428-429.

40. Sekine N., Yamamoto M., Michikawa M., Enomoto T., Hayashi M., Ozawa E., Kobayashi T. Rhabdomyolysis and acute renal failure in a patient with hypothyroidism // Internal. Medicine. 1993; 32: 269-271.

41. Gurkan S., Dikman S., Saland M.J. A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis // Pediatric. Nephrology. 2009; 24: 193-197. doi: 10.1007/s00467-007-0668-y.

42. Weetman A.P., Pinching A.J., Pussel B.A., Evans D.J., Sweny P., Rees A.J. Membranous glomerulonephritis and autoimmune thyroid disease // Clinical Nephrology. 1981; 15: 50-51.

43. Ikeda K., Maruyama Y., Yokoyama M., Kato N., Yamanoto H., Kaguchi Y., Nakayama M., Shimada T., Tojo K., Kawamura T., Hosoya T. Association of Graves’ disease with Evans’ syndrome in a patient with IgA nephropathy // Internal. Medicine. 2001; 40: 1004-1010.

44. Dizdar O., Kahraman S., Genctoy G., Ertoy D., Arici M., Altun B., Yasavul U., Turgan C. Membranoproliferative glome–rulonephritis associated with type 1 diabetes mellitus and Hashimoto’s thyroiditis // Nephrology. Dialysis. Transplantation. 2004; 19: 988-989.

45. Kagiyama S., Tsuruta H., Tominaga M., Morishita K., Doi Y., Onoyama K. Minimal-change nephrotic syndrome and acute renal failure in a patient with aged onset insulin-dependent diabetes mellitus and autoimmune thyroi–ditis // American Journal of Nephrology. 1999; 19: 369-372. doi: org/10.1159/000013479.

46. Brohee D., Delespesse G., Debisschop M.J., Bonnyns M. Circulating immune complexes in various thyroid diseases // Cli–nical and Experimental Immunology. 1979; 36: 379-383.

47. Calder E.A., Penhale W.J., Barnes E.W., Irvine W.J. Evidence for circulating immune complexes in thyroid disease // BMJ. 1974; 6: 30-31.

48. Ebihara I., Hirayama K., Usui J., Seki M., Higuchi F., Oteki T., Kobayashi M., Yamagata K. Tubulointerstitial nephritis and uveitis syndrome associated with hyperthyroidism // Clinical and Experimental Nephrology. 2006; 10: 216-221. doi: 10.1007/s10157-006-0423-x.

49. Hudde T., Heinz C., Neudorf U., Hoef S., Heiligenhaus A., Steuhl K.P. Tubulointerstitial nephritis and uveitis (TINU syndrome) — comorbidity and complications in four patients // Klinische Monatsblatter fur Augenheilkunde. 2007; 219: 528-532.

50. Paydas S., Balal M., Karayaylali I., Seyrek N. Severe acute renal failure due to tubulointerstitial nephritis, pancreatitis, and hyperthyroidism in a patient during rifampicin therapy // Advances in Therapy. 2005; 22: 241-243.

51. Matto T. Hypothyroidism in infants with nephrotic syndrome // Pediatric. Nephrology. 1994; 8: 657-659.

52. Silverberg D.S., Ulan R.A., Fawcett D.M., Dossetor J.B., Grace M., Bettcher K. Effects of chronic hemodialysis on thyroid function in chronic renal failure // Can. Med. Assoc. J. 1973; 109: 282-6.

53. Rodrigues M.C., Santos G.M., da Silva C.A., Baxter J.D., Webb P., Lomri N. et al. Thyroid hormone transport is disturbed in erythrocytes from patients with chronic renal failure on hemodialysis // Ren. Fail. 2004; 26: 461-6.

54. Junik R., Wlodarczyk Z., Masztalerz M., Odrowaz-Sypniewska G., Jendryczka E., Manitius J. Function, structure, and volume of thyroid gland following allogenic kidney transplantation // Transplant. Proc. 2003; 35: 2224-6.

55. Rotondi M., Netti G.S., Rosati A., Mazzinghi B., Magri F., Ronconi E. et al. Pretransplant serum FT3 levels in kidney graft recipients are useful for identifying patients with higher risk for graft failure // Clin. Endocrinol. (Oxf). 2008; 68: 220-5.

56. Acker C.G., Flick R., Shapiro R., Scantlebury V.P., Jordan M.L., Vivas C. et al. Thyroid hormone in the treatment of post-transplant acute tubular necrosis (ATN) // Am. J. Transplant. 2002; 2: 57-61.

57. Subramanian S., Goldstein D.P., Parlea L., Thabane L., Ezzat S., Ibrahim-Zada I., Straus S., Brierley J.D., Tsang R.W., Gafni A., Rotstein L., Sawka A.M. Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis // Thyroid. 2007; 17: 1277-1288. doi: 10.1089/thv.2007.0171.

58. Berthe E., Henry-Amar M., Michels J.J., Rame J.P., Berthet P., Babin E., Icard P., Samama G., Galateau-Salle´ F., Mahoudeau J., Bardet S. Risk of second primary cancer follo–wing differentiated thyroid cancer // European Journal of Nuclear Medicine and Molecular Imaging. 2004; 31: 685-691. doi: 10.1007/s00259-003-1448-y.

59. Vezzadini C., Cremonini N., Sforza A., Presutti L., Chiarini V. Treated Wilm’s tumor in childhood as potential risk factor for second thyroid cancer // Panminerva Medica. 2002; 44: 6 275-277.

60. Liou MJ, Lin JD, Chung MH, Liau CT & Hsueh C. Renal metastasis from papillary thyroid microcarcinoma // Acta Oto-Laryngologica. 2005; 125: 125 438-442. doi: 10.1080/00016480410022822.

61. Kumar A., Nadig M., Patra V., Srivastava D.N., Verma K., Bal C.S. Adrenal and renal metastases from follicular thyroid cancer // British Journal of Radiology. 2005; 78: 1038-1041. doi: 10.1259/bjr/24024066.

62. Oktay M.H., Smolkin M.B., Williams M., Cajigas A. Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma: report of a case of a challenging cytologic diagnosis // Acta Cytologica. 2006; 50: 201-204. doi: 10.1159/000325932.

63. Insabato L., Di V.D., De R.G., Prezioso D., Corcione F., Terracciano L.M. Renal metastasis from thyroid carcinoma 35 years after detection of the primary tumor // Tumori. 2003; 89: 99-101.

64. Eccles T.G., Patel A., Verma A., Nicholson D., Lukes Y., Tuttle R.M., Francis G.L. Erythropoietin and the erythropoietin receptor are expressed by papillary thyroid carcinoma from children and adolescents. Expression of erythropoietin receptor might be a favorable prognostic indicator // Annals of Clinical and Labo–ratory Science. 2003; 33: 411-422.

65. McIntyre E., Bond P., Douglas F., Lennard T., Peaston R., Perros P. Multiple endocrine neoplasia type 2A: an unusual clinical presentation and association with renal dysplasia // Cancer Genetics and Cytogenetics. 2003; 141: 157-159.

66. Calanas-Continente A., Espinosa M., Manzano-Garcıa G., Santamarı´a R., Lopez-Rubio F., Aljama P. Necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy // Thyroid. 2005; 15: 286-288. doi: 10.1089/thv.2005.15.286.

67. Bendz H., Aurell M. Adverse effects of lithium treatment and safety routines // Lakartidningen. 2004; 101: 1902-1906.

68. Kirk A.D., Hale D.A., Swanson S.J., Mannon R.B. Autoimmune thyroid disease after renal transplantation using depletional induction with alemtuzumab // American Journal of Transplantation. 2006; 6: 1084-1085. doi: 10.1111/j.1600-6143.2006.01258.x.

69. Stein E.M., Rivera C. Transient thyroiditis after treatment with lenalidomide in a patient with metastatic renal cell carcinoma // Thyroid. 2007; 17: 681-683. doi.org/10.1089/thy.2006.0294.

70. Umemoto S., Izumi K., Kanno H. Two cases of hyperthyroidism induced by interferon-alpha therapy for renal cell carcinoma // Hinyokika Kiyo. 2007; 53: 225-229.

71. Rini B.I., Tamaskar I., Shaheen P., Salas R., Garcia J., Wood L., Reddy S., Dreicer R., Bukowski R.M. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib // Journal of the National Cancer Institute. 2007; 99: 81-83. doi: 10.1093/jnci/djk008.

72. Garfield D.H., Hercbergs A., Davis P.J. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib // Journal of the National Cancer Institute. 2007; 99: 975-976. doi: org/10.1093/jnci/djm008.

73. Martino E., Bartalena L., Bogazzi F., Braverman L.E. The effects of amiodarone on the thyroid // Endocrine Reviews. 2001; 22: 240-254. doi: 10.1210/edrv.22.2.0427.

74. Morales A.I., Barata J.D., Bruges M., Arévalo M.A., González de Buitrago J.M., Palma P., Branco P., Pérez-Barriocanal F. Acute renal toxic effect of amiodarone in rats // Pharmacology & Toxicology. 2003; 92: 39-42. doi.org/10.1034/j.1600-0773.2003.920107.x.

75. Paydas S., Balal M., Karayaylali I., Seyrek N. Severe acute renal failure due to tubulointerstitial nephritis, pancreatitis, and hyperthyroidism in a patient during rifampicin therapy // Advances in Therapy. 2005; 22: 241-243.

76. Zoccali C., Tripepi G., Cutrupi S., Pizzini P., Mallamaci F. Low triiodothyronine: a new facet of inflammation in end-stage renal disease // Journal of the American Society of Nephro–logy. 2005; 16: 2789-2795. doi: 10.1681/ASN.2005040356.

Similar articles

Тиреоидная функция при сахарном диабете,   осложненном хронической болезнью почек
Authors: Сазонова Е.Г., Мохорт Т.В., Белорусский государственный медицинский университет УЗ «10-я городская поликлиника», г. Минск
International journal of endocrinology 2 (50) 2013
Date: 2013.04.22
Categories: Cardiology, Endocrinology
Sections: Specialist manual
Effect of Combination Treatment for Hypothyroidism on Renal Function in Patients with Hypothyroidism
Authors: Didushko O.M. - State Higher Educational Institution «Ivano-Frankivsk National Medical University», Ivano-Frankivsk; Pankiv V.I. - Ukrainian Scientific and Practical Centre for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Healthcare of Ukraine, Kyiv, Ukraine
International journal of endocrinology 1 (73) 2016
Date: 2016.03.25
Categories: Endocrinology
Sections: Clinical researches
Influence of certain components of metabolic syndrome on renal function in hypothyroidism (literature review)
Authors: O.M. Didushko
Higher State Education Institution “Ivano-Frankivsk National Medical University”, Ivano-Frankivsk, Ukraine

International journal of endocrinology Том 13, №6, 2017
Date: 2017.11.13
Categories: Endocrinology
Sections: Specialist manual
Authors: Б.А. Ребров, А.Б. Благодаренко, О.А. Реброва, Луганский государственный медицинский университет, кафедра внутренней медицины факультета последипломного образования
International journal of endocrinology 4(16) 2008
Date: 2009.02.09
Categories: Endocrinology
Sections: Specialist manual

Back to issue