International journal of endocrinology 2 (74) 2016
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Sert-Gene Polymorphism in the Patients with Thyrotoxicosis and Irritable Bowel Syndrome
Authors: Fediv O.I., Moskaliuk I.I. - Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine
Categories: Endocrinology
Sections: Medical forums
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The article was published on p. 184
Many studies have explored the role of genetic factors in the onset and progression of irritable bowel syndrome. In the study of familial inheritance irritable bowel syndrome, in 33 % of patients identified genetic predisposition to the disease, whereas in the general population, it was only 2 %. In recent years, increasingly studied polymorphisms of candidate genes associated with irritable bowel syndrome. It is known that in the regulation of intestinal motility and secretion are involved various neural and humoral mediators plays a particularly important neurotransmitter serotonin. Gene SERT, encodes a protein-synaptic serotonin transporter with a gap in the presynaptic membrane localized on chromosome 17 in the region of 17q11.2-q1. Depending on the type of gene polymorphism, L (long allele) and S (short allele) form 3 types of genotype: LL (long, long), LS (long-short) and SS (short-short).
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