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International journal of endocrinology 2 (74) 2016

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Sert-Gene Polymorphism in the Patients with Thyrotoxicosis and Irritable Bowel Syndrome

Authors: Fediv O.I., Moskaliuk I.I. - Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine

Categories: Endocrinology

Sections: Medical forums

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The article was published on p. 184


Many studies have explored the role of genetic factors in the onset and progression of irritable bowel syndrome. In the study of familial inheritance irritable bowel syndrome, in 33 % of patients identified genetic predisposition to the disease, whereas in the general population, it was only 2 %. In recent years, increasingly studied polymorphisms of candidate genes associated with irritable bowel syndrome. It is known that in the regulation of intestinal motility and secretion are involved various neural and humoral mediators plays a particularly important neurotransmitter serotonin. Gene SERT, encodes a protein-synaptic serotonin transporter with a gap in the presynaptic membrane localized on chromosome 17 in the region of 17q11.2-q1. Depending on the type of gene polymorphism, L (long allele) and S (short allele) form 3 types of genotype: LL (long, long), LS (long-short) and SS (short-short).

The aim of the study was to investigate SERT-gene polymorphism in patients with thyrotoxicosis and irritable bowel syndrome.
Material and methods. We investigated 38 women with diffuse toxic goiter and symptoms of irritable bowel syndrome. All of patients were examined for gene SERT, encoding the serotonin transporter protein. By the nature of violations of the digestive organs of patients divided into 3 groups. The first group included 12 patients with diffuse toxic goiter and with irritable bowel syndrome with diarrhea-type, the second group — ​12 patients with constipation. The third group consisted of 14 people with thyrotoxicosis without violations of the digestive system.
Results. In the first group of patients, we found all types of polymorphism: 67 % had a homozygous carrier LL alleles SERT, 25 % — ​SS-genotype, and only 1 patient (8 %) were heterozygous carriers of LS. Individuals of the second group tended to be short-allele carriers, in particular, 75 % of patients were heterozygous of LS, whereas 25 % had SS-genotype. In the analysis of a group of individuals without violating the intestinal function number of patients with SS-genotype (79 %) was significantly dominated by the number of LS-heterozygotes (21 %).
Conclusion. It was found that the type of intestinal dysfunction in diffuse toxic goiter is associated with gene polymorphism SERT, which raises the need for correction of medical tactics in these patients.

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