Інформація призначена тільки для фахівців сфери охорони здоров'я, осіб,
які мають вищу або середню спеціальну медичну освіту.


Підтвердіть, що Ви є фахівцем у сфері охорони здоров'я.

 

International journal of endocrinology 2 (74) 2016

Back to issue

Sert-Gene Polymorphism in the Patients with Thyrotoxicosis and Irritable Bowel Syndrome

Authors: Fediv O.I., Moskaliuk I.I. - Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine

Categories: Endocrinology

Sections: Medical forums

print version

The article was published on p. 184

 

Many studies have explored the role of genetic factors in the onset and progression of irritable bowel syndrome. In the study of familial inheritance irritable bowel syndrome, in 33 % of patients identified genetic predisposition to the disease, whereas in the general population, it was only 2 %. In recent years, increasingly studied polymorphisms of candidate genes associated with irritable bowel syndrome. It is known that in the regulation of intestinal motility and secretion are involved various neural and humoral mediators plays a particularly important neurotransmitter serotonin. Gene SERT, encodes a protein-synaptic serotonin transporter with a gap in the presynaptic membrane localized on chromosome 17 in the region of 17q11.2-q1. Depending on the type of gene polymorphism, L (long allele) and S (short allele) form 3 types of genotype: LL (long, long), LS (long-short) and SS (short-short).

The aim of the study was to investigate SERT-gene polymorphism in patients with thyrotoxicosis and irritable bowel syndrome.
Material and methods. We investigated 38 women with diffuse toxic goiter and symptoms of irritable bowel syndrome. All of patients were examined for gene SERT, encoding the serotonin transporter protein. By the nature of violations of the digestive organs of patients divided into 3 groups. The first group included 12 patients with diffuse toxic goiter and with irritable bowel syndrome with diarrhea-type, the second group — ​12 patients with constipation. The third group consisted of 14 people with thyrotoxicosis without violations of the digestive system.
Results. In the first group of patients, we found all types of polymorphism: 67 % had a homozygous carrier LL alleles SERT, 25 % — ​SS-genotype, and only 1 patient (8 %) were heterozygous carriers of LS. Individuals of the second group tended to be short-allele carriers, in particular, 75 % of patients were heterozygous of LS, whereas 25 % had SS-genotype. In the analysis of a group of individuals without violating the intestinal function number of patients with SS-genotype (79 %) was significantly dominated by the number of LS-heterozygotes (21 %).
Conclusion. It was found that the type of intestinal dysfunction in diffuse toxic goiter is associated with gene polymorphism SERT, which raises the need for correction of medical tactics in these patients.

Similar articles

Effects of the Thyroid Status Correction on the Functional State of Digestive System in Children with Diffuse Nontoxic Goiter
Authors: Mamenko M.Ye., Bugayenko O.O. - State Institution «Lugansk State Medical University», Lugansk, Ukraine
"Child`s Health" 8 (51) 2013
Date: 2014.01.14
Categories: Pediatrics/Neonatology
Sections: Clinical researches
Influence of Distribution of Type I Deiodinase Gene Polymorphism on Indices of Thyroid Homeostasis in Patients with Chronic Hepatitis and Nonviral Liver Cirrhosis
Authors: Chympoi K.A. - Department of Internal Medicine, Higher State Educational Institution of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine; Pashkovska N.V. - Department of Clinical Immunology, Allergology and Endocrinology, Higher State Educational Institution of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine; Pavliukovych N.D. - Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases, Higher State Educational Institution of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine; Korotash I.F., Rybak O.Ya., Misechko A.I. - Higher State Educational Institution of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine
International journal of endocrinology 2 (74) 2016
Date: 2016.05.12
Categories: Endocrinology
Sections: Clinical researches
Genetic Polymorphism of Toll-like Receptor 4 — Predictor of Susceptibility to Recurrent Course of Chronic Pyelonephritis in Children
Authors: Kryuchko T.A., Ostapenko V.P., Kushnereva T.V. - Higher State Educational Institution of Ukraine «Ukrainian Medical Stomatological Academy», Poltava, Ukraine
"Child`s Health" 7 (50) 2013
Date: 2013.12.09
Categories: Nephrology, Pediatrics/Neonatology
Sections: Clinical researches

Back to issue