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Association between bone turnover markers and leptin in girls with adolescent idiopathic scoliosis

Authors: Matusik E., Durmala J. - School of Health Sciences, Department of Rehabilitation, Medical University of Silesia, Katowice, Poland; Olszanecka-Glinianowicz M. - School of Medicine in Katowice, Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland; Chudek J. - School of Medicine in Katowice, Pathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland; Matusik P. - School of Medicine in Katowice, Department of Pediatrics, and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland

Categories: Rheumatology, Traumatology and orthopedics

Sections: Medical forums

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The article was published on p. 78

 

The link between scoliotic deformity and bone metabolism in adolescent idiopathic scoliosis (AIS) has not been well researched. Moreover, the data concerning the cross-talk between leptin level and bone markers in this group of patients are lacking. 

The objective of this study was to correlate the extent of scoliotic-curve severity with the bone turnover and leptin level in girls with AIS. 
The study encompassed 77 AIS girls, aged 14.70 ± 2.17 years. Scoliotic curve severity assessed by Cobb’s angle was categorized as mild (10–19o) moderate (20–39°) or severe (≥ 40°). Corrected height, weight, waist and hip circumferences were measured and body mass index (BMI), corrected height Z-score, BMI Z-score and waist/height ratio (WHtR) and were calculated for the entire group. Body composition parameters: fat mass (FAT), fat-free mass (FFM) and predicted muscle mass (PMM) were determined using a bioelectrical impedance analyzer. Bone turnover markers (osteocalcin (OC) and amino terminal of collagen cross-links NTx) and leptin levels were assessed in serum. 
Multiple regression analysis showed that, OC, NTx (negatively with p < 0.05) and leptin (positively with p < 0.01) were significantly associated with curve severity in AIS girls. Moreover, Cobb’s angle was positively correlated with W/HtR (p < 0.01) and FAT (p < 0.05). One-way analysis of variance (ANOVA) revealed significant differences in leptin (p < 0.05 vs. mild only), OC (p < 0.05 vs. mild and moderate)) and W/HtR (p < 0.01 and p < 0.05 vs. mild and moderate respectively) between the three scoliotic severity subgroups. OC was significantly lower in the severe AIS subgroup, while leptin and W/HtR were significantly higher. Significant correlations between leptin and anthropometrical parameters as BMI z-score and W/HtR were shown. Leptin level correla-ted also significantly with BMI z score (p < 0.001), W/HtR (p < 0.0001) and body composition parameters (p < 0.000001). Moreover, there was a significant negative correlation between NTx and leptin level (p < 0.05). Bone metabolism in AIS girls seems to altered and significantly related to the scoliotic curve severity. Leptin may be a crucial link in the cross-talk between bone turnover and body composition in this group of patients. 
Further studies concerning this topic are needed. 

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