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"Child`s Health" Том 12, №2, 2017

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Development of the immune response in pneumonia due to Staphylococcus aureus (part 1)

Authors: Абатуров А.Е., Никулина А.А.
ГУ «Днепропетровская медицинская академия МЗ Украины», г. Днепр, Украина

Categories: Pediatrics/Neonatology

Sections: Specialist manual

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Summary

В огляді літератури викладені сучасні дані про патоген-асоційовані молекулярні структури Staphylococcus aureus та його роль у виникненні пневмонії: активації і модуляції імунної відповіді, оксидативного і метаболічного стресу, апоптозу клітин. Особливу увагу приділено факторам вірулентності збудника, які можуть індукувати запальний процес без активації образ-розпізнавальних рецепторів.

В обзоре литературы изложены современные данные о патоген-ассоциированных молекулярных структурах Staphylococcus aureus и его роли в возникновении пневмонии: активации и модулировании иммунного ответа, оксидативного и метаболического стресса, апоптозе клеток. Особое внимание уделено факторам вирулентности возбудителя, которые могут индуцировать воспалительный процесс без активации образ-распознающих рецепторов.

The literature review presents modern data on the pathogen-associated molecular structures of Staphylococcus aureus and its role in the occurrence of pneumonia: activation and modulation of the immune response, oxidative and metabolic stress, apoptosis. Particular attention is paid to the factors of virulence of the pathogen, which can induce an inflammatory process without activating the image-recognition receptors.


Keywords

пневмонія; Staphylococcus aureus; імунна відповідь; патоген-асоційовані молекулярні структури; огляд

пневмония; Staphylococcus aureus; иммунный ответ; патоген-ассоциированные молекулярные структуры; обзор

pneumonia; Staphylococcus aureus; immune response; pathogen-associated molecular patterns; review


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