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"Gastroenterology" Том 52, №4, 2018

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B.coagulans in the treatment of gastrointestinal diseases of inflammatory and functional nature: effectiveness from the standpoint of evidence-based medicine

Authors: Высочина И.Л.
ГУ «Днепропетровская медицинская академия Министерства здравоохранения Украины», г. Днепр, Украина

Categories: Gastroenterology

Sections: Specialist manual

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Summary

Проведено аналіз баз даних PubMed, Scopus, Web of Science, MedLine, The Cochrane Library, CyberLeninka, РІНЦ у контексті пошуку інформації щодо ефективності B.coagullans у лікуванні гастроентерологічних захворювань запальної і функціональної природи. Системний аналіз інформації, наведений у даній статті, повністю відповідає міжнародним рекомендаціям щодо систематичних методів пошуку літератури і містить інформацію про роль, значення, переваги, безпеку та ефективність даного штаму (GRAS Notice No. GRN 000660) і можливості застосування пробіотиків і препаратів B.сoagulans у людини, з доказовою базою можливості розширення показань для застосування споровмісних пробіотиків B.coagullans (у тому числі і для препарату Лактовіт Форте), зокрема при синдромі подразненого кишечника.

Проведен анализ баз данных PubMed, Scopus, Web of Science, MedLine, The Cochrane Library, CyberLeninka, РИНЦ в контексте поиска информации по эффективности B.coagullans в лечении гастроэнтерологических заболеваний воспалительной и функциональной природы. Системный анализ информации, представленный в данной статье, полностью соответствует международным рекомендациям по систематическим методам поиска литературы и содержит информацию о роли, значении, преимуществах, безопасности и эффективности данного штамма (GRAS Notice No. GRN 000660) и возможностях применения пробиотиков и препаратов B.сoagulans у человека с доказательной базой возможности расширения показаний для применения споросодержащих пробиотиков B.coagullans (в том числе и для препарата Лактовит Форте), в частности при синдроме раздраженного кишечника.

The analysis of PubMed, Scopus, Web of Science, MedLine, The Cochrane Library, CyberLeninka, RISC databases was performed in the context of searching for information on the effectiveness of B.coagulans in the treatment of gastrointestinal diseases of inflammatory and functional nature. The system analysis of the information presented in this article fully complies with international recommendations on systematic methods of literature search and contains information on the role, significance, advantages, safety and effectiveness of this strain (GRAS Notice No. GRN 000660) and the options of using probiotics and B.coagulans preparations in humans, with evidence of the possibility of expanding indications for the administration of the probiotic B.coagulans (Laktovit Forte), in particular in irritable bowel syndrome.


Keywords

огляд; B.coagullans; Лактовіт Форте; гастроентерологічні захворювання запальної і функціональної природи

обзор; B.coagullans; Лактовит Форте; гастроэнтерологические заболевания воспалительной и функциональной природы

review; B.coagulans; Laktovit Forte; gastrointestinal diseases of inflammatory and functional nature


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Bibliography

1. Abdhul K., Ganesh M., Shanmughapriya S., Vanithamani S., Kanagavel M., Anbarasu K. et al. Bacteriocinogenic potential of a probiotic strain Bacillus coagulans [BDU3] from Ngari // Int. J. Biol. Macromol. 2015; 79: 800-806. 10.1016/j.ijbiomac.2015.06.005

2. Abhari K., Shekarforoush S.S., Hosseinzadeh S., Nazifi S., Sajedianfard J., Eskandari M.H. The effects of orally administered Bacillus coagulans and inulin on prevention and progression of rheumatoid arthritis in rats // Food Nutr. Res. 2016; 60: 30876 10.3402/fnr.v60.30876

3. Adami A., Cavazzoni V. Occurrence of selected bacterial groups in the faeces of piglets fed with Bacillus coagulans as probiotic // J. Basic Microbiol. 1999; 39: 3-10. 10.1002/(SICI)1521-4028(199903)39:1<3:AID-JOBM3>3.0.CO;2-O

4. Adewumi G.A., Oguntoyinbo F.A., Romi W., Singh T.A., Jeyaram K. Genome subtyping of autochthonous Bacillus species isolated from Iru, a fermented Parkia biglobosa seed // Food Biotechnol. 2014; 28: 250-268. 10.1080/08905436.2014.931866

5. Ash et al. Phylogenetic heterogeneity of the genus Bacillus revealed by comparative analysis of small-subunit-ribosomal RNA sequences // Lett. Appl. Microbiol. 1991; 13: 202-206.

6. Alou et al. Bacillus rubiinfantis sp. nov. strain mt2T, a new bacterial species isolated from human gut // New Microbes New Infect. 2015; 8: 51-60.

7. Alkaya B., Laleman I., Keceli S., Ozcelik O., Cenk Haytac M., Teughels W. Clinical effects of probiotics containing Bacillus species on gingivitis: a pilot randomized controlled trial // J. Periodontal. Res. 2016; 52: 497-504. 10.1111/jre.12415

8. Alou M.T., Rathored J., Khelaifia S., Michelle C., Brah S., Diallo B.A. et al. Bacillus rubiinfantis sp. nov. strain mt2T, a new bacterial species isolated from human gut // New Microbes New Infect. 2015; 8: 51-60. 10.1016/j.nmni.2015.09.008

9. Altmeyer S., Kröger S., Vahjen W., Zentek J., Scharek-Tedin L. Impact of a probiotic Bacillus cereus strain on the jejunal epithelial barrier and on the NKG2D expressing immune cells during the weaning phase of piglets // Vet. Immunol. Immunopathol. 2014; 161: 57-65. 10.1016/j.vetimm.2014.07.001

10. Angmo K., Kumari A., Bhalla T.C. Probiotic characterization of lactic acid bacteria isolated from fermented foods and beverage of Ladakh // LWT Food Sci. Technol. 2016; 66: 428-435. 10.1016/j.lwt.2015.10.057

11. Aminlari L., Shekarforoush S.S., Hosseinzadeh S., Nazifi S., Sajedianfard J., Eskandari M.H. Effect of Probiotics Bacillus coagulans and Lactobacillus plantarum on Lipid Profile and Feces Bacteria of Rats Fed Cholesterol-Enriched Diet // Probiotics Antimicrob. Proteins. 2018 Oct 27.

12. Ash C., Farrow J.A.E., Wallbanks S., Collins M.D. Phylogenetic heterogeneity of the genus Bacillus revealed by comparative analysis of small-subunit-ribosomal RNA sequences // Lett. Appl. Microbiol. 1991; 13: 202-206. 10.1111/j.1472-765X

13. Bader J., Albin A., Stahl U. Spore-forming bacteria and their utilisation as probiotics // Benef. Microbes. 2012; 3: 67-75. 10.3920/BM2011.0039

14. Beaumont M. Flavouring composition prepared by fermentation with Bacillus spp. // Int. J. Food Microbiol. 2002; 75: 189-196. 10.1016/S0168-1605(01)00706-1

15. Bergey D. Bergey’s Manual of Determinative Bacteriology. 9th ed. — Baltimore, MD: The Williams and Wilkens Company, 1993.

16. Berthold-Pluta A., Pluta A., Garbowska M. The effect of selected factors on the survival of Bacillus cereus in the human gastrointestinal tract // Microb. Pathog. 2015; 82: 7-14. 10.1016/j.micpath.2015.03.015

17. Bohm M.E., Huptas C., Krey V.M., Scherer S. Massive horizontal gene transfer, strictly vertical inheritance and ancient duplications differentially shape the evolution of Bacillus cereusenterotoxin operons hbl, cytK and nhe // BMC Evol. Biol. 2015; 15: 246 10.1186/s12862-015-0529-4

18. Butel M.J. Probiotics, gut microbiota and health // Med. Mal. Infect. 2014; 44: 1-8. 10.1016/j.medmal.2013.10.002

19. Cai D., Liu M., Wei X., Li X., Wang Q., Nomura C.T., et al. Use of Bacillus amyloliquefaciens HZ-12 for high-level production of the blood glucose lowering compound, 1-deoxynojirimycin (DNJ), and nutraceutical enriched soybeans via fermentation // Appl. Biochem. Biotechnol. 2017; 181: 1108-1122. 10.1007/s12010-016-2272-8

20. Casula G., Cutting S. M. Bacillus probiotics: spore germination in the gastrointestinal tract // Appl. Environ. Microbiol. 2002; 68: 2344-2352. 10.1128/AEM.68.5.2344-2352.2002

21. Chantawannakul P., Oncharoen A., Klanbut K., Chukeatirote E., Lumyong S. Characterization of proteases of Bacillus subtilis strain 38 isolated from traditionally fermented soybean in northern // Thailand. Sci. Asia. 2002; 28: 241-245. 10.2306/scienceasia1513-1874.2002.28.241

22. Ghelardi E., Celandroni F., Salvetti S., Gueye S.A., Lupetti A., Senesi S. Survival and persistence of Bacillus clausii in the human gastrointestinal tract following oral administration as spore-based probiotic formulation // J. Appl. Microbiol. 2015; 119(2): 552-9.

23. Choi J.H., Pichiah P.B.T., Kim M.J., Cha Y.S. Cheonggukjang, a soybean paste fermented with B. licheniformis 67 prevents weight gain and improves glycemic control in high fat diet induced obese mice // J. Clin. Biochem. Nutr. 2016; 59: 31-38. 10.3164/jcbn.15-30

24. Cutting S.M. Bacillus probiotics // Food Microbiol. 2011; 28: 214-220. 10.1016/j.fm.2010.03.007

25. De Vecchi E. Lactobacillus sporogenes or Bacillus coagulans: misidentification or mislabelling? [Text] / E. De Vecchi, L. Drago // International Journal of Probiotics and Prebiotics. 2006; Vol. 1, № 1: P. 3-10.

26. Devid Kelle, Sean Farme, Anne McCartney and Glenn Gibson, Ganeden Biotech, Mayfield Heights, Bacillus coagulans as a probiotic. — Ohio, USA, Food Microbial Sciences Unit, Department of Food and Nutritional Sciences, University of Reading, Reading.

27. Di Caro S., Tao H., Grillo A., Franceschi F., Elia C., Zocco M.A. et al. Bacillus clausiieffect on gene expression pattern in small bowel mucosa using DNA microarray analysis // Eur. J. Gastroenterol. Hepatol. 2005; 17: 951-960. 10.1097/00042737-200509000-00011

28. Doron S., Snydman D.R. Risk and safety of probiotics // Clin. Infect. Dis. 2015; 60: S129-S134. 10.1093/cid/civ085

29. Drago L., Rodighiero V., Celeste T., Rovetto L., De Vecchi E. Microbiological evaluation of commercial probiotic products available in the United States in 2009 // J. Chemother. 2013; 22: 373-377. 10.1179/joc.2010.22.6.373

30. Duc L.H., Hong H.A., Barbosa T.M., Henriques A.O., Cutting S.M. Characterization of Bacillus probiotics available for human use // Appl. Environ. Microbiol. 2004; 70: 2161-2171. 10.1128/AEM.70.4.2161-2171.2004

31. Dudonné S., Varin T.V., Anhê F.F., Dubé P., Roy D., Pilon G. et al. Modulatory effects of a cranberry extract co-supplementation with Bacillus subtilis CU1 probiotic on phenolic compounds bioavailability and gut microbiota composition in high-fat diet-fed mice // Pharma Nutr. 2015; 3: 89-100. 10.1016/j.phanu.2015.04.002

32. Earl A.M., Eppinger M., Fricke W.F., Rosovitz M.J., Rasko D.A., Daugherty S. et al. Whole-genome sequences of Bacillus subtilis and close relatives // J. Bacteriol. 2012; 194: 2378-2379. 10.1128/JB.05675-11

33. Elshaghabee F.M.F., Rokana N., Gulhane R.D., Sharma C., Panwar H. Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives // Front Microbiol. 2017 Aug 10; 8: 1490.

34. Endres J.R., Clewell A., Jade K.A., Farber T., Hauswirth J., Schauss A.G. Safety assessment of a proprietary preparation of a novel probiotic, Bacillus coagulans, as a food ingredient // Food Chem. Toxicol. 2009; 47: 1231-1238. 10.1016/j.fct.2009.02.018

35. Fakhry S., Sorrentini I., Ricaa E., De Felice M., Baccigalupi L. Characterization of spore forming Bacilli isolated from the human gastrointestinal tract // J. Appl. Microbiol. 2008; 105: 2178-2186. 10.1111/j.1365-2672.2008.03934.x

36. Fan B., Blom J., Klenk H.P., Borriss R. Bacillus amyloliquefaciens, Bacillus velezensis and Bacillus siamensis form an operational group B. amyloliquefaciens within the B. subtilis species complex // Front. Microbiol. 2017; 8: 22 10.3389/fmicb.2017.00022

37. FAO/WHO. Health and Nutritional Properties of Probiotics in Food Including Powder Milk With Live Lactic Acid Bacteria. Report of a joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria — Rome: Food and Agriculture Organization, 2001.

38. FAO/WHO. Guidelines for the Evaluation of Probiotics in Food. Food and Agriculture Organization of the United Nations and World Health Organization Working Group Report. — Rome: Food and Agriculture Organization, 2002.

39. Fouad M.F. Elshaghabee, Namita Rokana, Rohini D. Gulhane, Chetan Sharma and Harsh Panwar. Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives // Front Microbiol. 2017; 8: 1490.

40. Fujiya M., Musch M. W., Nakagawa Y., Hu S., Alverdy J., Kohgo Y. et al. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter // Cell Host. Microbe. 2007; 1: 299-308. 10.1016/j.chom.2007.05.004

41. Ghani M., Ansari A., Aman A., Zohra R.R., Siddiqui N.N., Qader S.A.U. Isolation and characterization of different strains of Bacillus licheniformis for the production of commercially significant enzymes // Pak. J. Pharm. Sci. 2013; 26: 691-697.

42. Ghandi A.B. Lactobacillus sporogenes, an advancement in Lactobacillus therapy // East. Pharm. 1988; 41-43.

43. Ghelardi E., Celandroni F., Salvetti S., Gueye S.A., Lupetti A., Senesi S. Survival and persistence of Bacillus clausii in the human gastrointestinal tract following oral administration as spore-based probiotic formulation // J. Appl. Microbiol. 2015; 119: 552-559. 10.1111/jam.12848

44. Ghoneim M.A.M., Hassan A.I., Mahmoud M.G., Asker M.S. Effect of polysaccharide from Bacillus subtilis sp. on cardiovascular diseases and atherogenic indices in diabetic rats // BMC Complement. Altern. Med. 2016; 16:112 10.1186/s12906-016-1093-1

45. Gobi N., Malaikozhundan B., Sekar V., Shanthi S., Vaseeharan B., Jayakumar R. et al. GFP tagged Vibrio parahaemolyticus Dahv2 infection and the protective effects of the probiotic Bacillus licheniformis Dahb1 on the growth, immune and antioxidant responses in Pangasius hypophthalmus // Fish Shellfish Immunol. 2016; 52: 230-238. 10.1016/j.fsi.2016.03.006

46. Green D.H., Wakeley P.R., Page A., Barnes A., Baccigalupi L., Ricca E. et al. Characterization of two bacillus probiotics // Appl. Environ. Microbiol. 1999; 65: 4288-4291.

47. Guo Z., Liu X.M., Zhang Q.X., Shen Z., Tian F.W., Zhang H. et al. Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomized controlled trials // Nutr. Metab. Cardiovasc. Dis. 2013; 21: 844-850. 10.1016/j.numecd.2011.04.008

48. Harue Honda, Lesley Hoyles, Glenn R. Gibson, Sean Farmer, David Keller and Anne L. McCartney // Impact of Ganeden BC30 (Bacillus coagulans GBI-30, 6086) on population dynamics of the human gut microbiota in a continuous culture fermentation system // International Journal of Probiotics and Prebiotics. 2011; 6(1): 65-72.

49. Ganesh M., Shanmughapriya S., Vanithamani S., Kanagavel M., Anbarasu K., Natarajaseenivasan K. Bacteriocinogenic potential of a probiotic strain Bacillus coagulans [BDU3] from Ngari/Abdhul K. // International Journal of Biological Macromolecules. 2015.

50. Hoffman T., Troup P., Szabo A., Hungerer C., Jahn D. The anaerobic life of Bacillus subtilis: cloning of the genes encoding the respiratory nitrate reductase system // FEMS Microbiol. Lett. 1995; 131: 219-225. 10.1111/j.1574-6968.1995.tb07780.x

51. Hong H.A., Duc le H., Cutting S.M. The use of bacterial spore formers as probiotics // FEMS Microbiol. Rev. 2005; 29: 813-835. 10.1016/j.femsre.2004.12.001

52. Hong H.A., Huang J.M., Khaneja R., Hiep L.V., Urdaci M.C., Cutting S.M. The safety of Bacillus subtilis and Bacillus indicus as food probiotics // J. Appl. Microbiol. 2008; 105: 510-520. 10.1111/j.1365-2672.2008.03773.x

53. Hong H.A., Khaneja R., Tam N.M.K., Cazzato A., Tan S., Urdaci M. et al. Bacillus subtilis isolated from the human gastrointestinal tract // Res. Microbiol. 2009; 160: 134-143. 10.1016/j.resmic.2008.11.002

54. Horosheva T.V., Vodyanoy V., Sorokulova I. Efficacy of Bacillus probiotics in prevention of antibiotic-associated diarrhoea: a randomized, double-blind, placebo-controlled clinical trial // JMM Case Rep. 2014; 1: 1-6. 10.1099/jmmcr.0.004036

55. Hosoi T., Kiuchi K. Natto — a food made by fermenting cooked soybeans with Bacillus subtilis (natto) // Handbook of Fermented Functional Foods / Ed. by Farnworth E.R. (Boca Raton, FL: CRC Press). 2003; 227-245.

56. Hoyles L., Honda H., Logan N.A., Halket G., La Ragione R.M., McCartney A.L. Recognition of greater diversity of Bacillus species and related bacteria in human faeces. Res. Microbiol. 2012; 163: 3-13. 10.1016/j.resmic.2011.10.004

57. Hyronimus B., Le Marrec C., Sassi A.H., Deschamps A. Acid and bile tolerance of spore-forming lactic acid bacteria // Int. J. Food Microbiol. 2000; 61: 193-197. 10.1016/S0168-1605(00)00366-4

58. Hyronimus B., Le Marrec C., Urdaci M.C. Coagulin, a bacteriocin-like inhibitory substance produced by Bacillus coagulans I4 // J. Appl. Microbiol. 1998; 85: 42-50.

59. Jager R., Shields K.A., Lowery R.P., De Souza E.O., Partl J.M., Hollmer C. et al. Probiotic Bacillus coagulans GBI-30, 6086 reduces exercise-induced muscle damage and increases recovery // Peer J. 2016; 4: e2276 10.7717/peerj.2276

60. Jeong H., Park S.H., Choi S.K. Draft genome sequences of four plant probiotic Bacillusstrains // Genome Announc. 2016; 4: e00358-16. 10.1128/genomeA.00358-16

61. Jensen G.S., Cash H.A., Farmer S., Keller D. Inactivated probiotic Bacillus coagulansGBI-30 induces complex immune activating, anti-inflammatory, and regenerative markers in vitro // Journal of inflammation research. 2017; 10: 107-117.

62. Joseph B., Dhas B., Hena V., Raj J. Bacteriocin from Bacillus subtilis as a novel drug against diabetic foot ulcer bacterial pathogens // Asian Pac. J. Trop. Biomed. 2013; 3: 942-946. 10.1016/S2221-1691(13)60183-5

63. Kalliomäki M., Salminen S., Arvilommi H., Kero P., Koskinen P., Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial // Lancet. 2001; 357: 1076-1079. 10.1016/S0140-6736(00)04259-8

64. Karu R., Sumeri I. Survival of Lactobacillus rhamnosus GG during simulated gastrointestinal conditions depending on food matrix // J. Food Res. 2016; 5: 57-66. 10.5539/jfr.v5n5p56

65. Keller D., Van Dinter R., Cash H., Farmer S., Venema K. Bacillus coagulans GBI-30, 6086 increases plant protein digestion in a dynamic, computer-controlled in vitro model of the small intestine // Beneficial microbes. 2017; 8: 491-496.

66. Khochamit N., Siripornadulsil S., Sukon P., Siripornadulsil W. Antibacterial activity and genotypic-phenotypic characteristics of bacteriocin-producing Bacillus subtilis KKU213: potential as a probiotic strain // Microbiol. Res. 2015; 170: 36-50. 10.1016/j.micres.2014.09.004

67. Khodadad A., Farahmand F., Najafi M., Shoaran M. Probiotics for the treatment of pediatric Helicobacter pylori infection: a randomized double blind clinical trial // Iran. J. Pediatr. 2013; 23: 79-84.

68. Kotb E. Purification and partial characterization of serine fibrinolytic enzyme from Bacillus megaterium KSK-07 isolated from kishk, a traditional Egyptian fermented food // Appl. Biochem. Microbiol. 2015; 51: 34-43.

69. Kniehl E., Becker A., Forster D. H. Pseudo-outbreak of toxigenic Bacillus cereus isolated from stools of three patients with diarrhoea after oral administration of a probiotic medication // J. Hosp. Infect. 2003; 55: 33-38. 10.1016/S0195-6701(03)00133-6

70. Kodali V.P., Sen R. Antioxidant and free radical scavenging activities of an exopolysaccharide from a probiotic bacterium // Biotechnol J. 2008; 3: 245-251.

71. Kolsto A.B., Tourasse N.J., Okstad O.A. What sets Bacillus anthracis apart from other Bacillus species // Annu. Rev. Microbiol. 2009; 63: 451-476. 10.1146/annurev.micro.091208.073255

72. Krawczyk A.O., de Jong A., Holsappel S., Eijlander R.T., van Heel A., Berendsen E.M. et al. Genome sequences of 12 spore-forming Bacillus species, comprising Bacillus coagulans, Bacillus licheniformis, Bacillus amyloliquefaciens, Bacillus sporothermodurans, and Bacillus vallismortis, isolated from foods // Genome Announc. 2016; 4: 103-116. 10.1128/genomeA.00103-16

73. Lee J.H., Nam S.H., Seo W.T., Yun H.D., Hong S.Y., Kim M.K. et al. The production of surfactin during the fermentation of cheonggukjang by potential probiotic Bacillus subtilis CSY191 and the resultant growth suppression of MCF-7 human breast cancer cells // Food Chem. 2012; 131: 1347-1354. 10.1016/j.foodchem.2011.09.133

74. Lefevre M., Racedo S.M., Ripert G., Housez B., Cazaubiel M., Maudet C.P. et al. Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study // Immun. Ageing. 2015; 12: 24 10.1186/s12979-015-0051-y

75. London L.E., Kumar A.H., Wall R., Casey P.G., O’Sullivan O., Shanahan F. et al. Exopolysaccharide-producing probiotic Lactobacilli reduce serum cholesterol and modify enteric microbiota in ApoE-deficient mice // J. Nutr. 2014; 144: 1956-1962. 10.3945/jn.114.191627

76. Haldar L., Gandhi D.N. Effect of oral administration of Bacillus coagulans B37 and Bacillus pumilus B9 strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model // Vet. World. 2016; 9(7): 766-772.

77. Lopetuso L.R., Scaldaferri F., Franceschi F., Gasbarrini A. Bacillus clausii and gut homeostasis: state of the art and future perspectives // Expert. Rev. Gastroenterol. Hepatol. 2016; 10: 943-948. 10.1080/17474124

78. Majeed M., Prakash L. Lactospore: The Effective Probiotic. Piscataway, NJ: Nutri Science Publishers, Inc.; 1998.

79. Mallappa R.H., Rokana N., Duary R.K., Panwar H., Batish V.K., Grover S. Management of metabolic syndrome through probiotic and prebiotic interventions // Indian J. Endocrinol. Metab. 2012; 1620-27. 10.4103/2230-8210.91178

80. Maneerat S., Lehtinen M.J., Childs C.E., Forssten S.D., Alhoniemi E., Tiphaine M. et al. Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes // J. Nutr. Sci. 2014; 44: 1-10. 10.1017/jns.2013.31

81. Mandel D.R., Eichas K., Holmes J. Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial // BMC Complement Altern. Med. 2010; 10: 1.

82. Manhar A.K., Bashir Y., Saikia D., Nath D., Gupta K., Konwar B.K. et al. Cellulolytic potential of probiotic Bacillus Subtilis AMS6 isolated from traditional fermented soybean (Churpi): An in-vitro study with regards to application as an animal feed additive // Microbiol. Res. 2016; 186: 62-70. 10.1016/j.micres.2016.03.004

83. Mohammed Y., Lee B., Kang Z., Du G. Development of a two-step cultivation strategy for the production of vitamin B12 by Bacillus megaterium // Microb. Cell Fact. 2014; 13: 102 10.1186/s12934-014-0102-7

84. Mullany P., Barbosa T.M., Scott K., Roberts A.P. (2004). Mechanisms of gene transfer and the spread of antibiotic resistance in spore forming organisms in the GI tract, in Bacterial Spore Formers: Probiotics and Emerging Applications / Ricca E., Henriques A.O., Cutting S.M., editors. — Norfolk: Horizon Bioscience, 2004. — Р.  113-129.

85. Muscettola M., Grasso G., Blach-Olszewska Z., Migliaccio P., Borghesi-Nicoletti C., Giarratan M. et al. Effects of Bacillus subtilis spores on interferon production // Pharmacol. Res. 1992; 26: 176-177. 10.1016/1043-6618(92)90652-R

86. Muscettola M., Grasso G., Migliaccio P., Gallo V.C. Plasma interferon-like activity in rabbits after oral administration of Bacillus subtilis spores // J. Chemother. 1991; 3: 130-132.

87. Nagal S., Okimura K., Kaizawa N., Ohki K., Kanatomo S. Study on surfactin, a cyclic depsipeptide II synthesis of surfactin B2 produced by Bacillus natto KMD 2311 // Chem. Phar. Bull. (Tokyo). 1996; 44: 5-10. 10.1248/cpb.44.5

88. Nyangale E.P., Farmer S., Cash K., Chernoff D., Gibson G.R. Bacillus coagulans GBI-30 6086 modulates Faecalibacterium prausnitziiin older men and women // J. Nutr. 2015; 145: 1446-1452. 10.3945/jn.114.199802

89. Nyangale E.P., Farmer S., Keller D., Chernoff D., Gibson G.R. Effect of prebiotics on the fecal microbiota of elderly volunteers after dietary supplementation of Bacillus coagulans GBI-30, 6086 // Anaerobe. 2014; 30: 75-81. 10.1016/j.anaerobe.2014.09.002

90. Ouattara H.G., Reverchon S., Niamke S.L., Nasser W. Regulation of the synthesis of pulp degrading enzymes in Bacillus isolated from cocoa fermentation // Food Microbiol. 2017; 63: 255-262. 10.1016/j.fm.2016.12.004

91. Panwar H., Calderwood D., Grant I.R., Grover S., Green B.D. Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha-and beta-glucosidases suggesting anti-diabetic potential // Eur. J. Nutr. 2014; 53: 1465-1474. 10.1007/s00394-013-0649-9

92. Panwar H., Calderwood D., Grant I.R., Grover S., Green B.D. Lactobacilli possess inhibitory activity against dipeptidyl peptidase-4 (DPP-4) // Ann. Microbiol. 2016; 66; 505-509. 10.1007/s13213-015-1129-7

93. Pinchuk I.V., Bressollier P., Verneuil B., Fenet B., Sorokulova I.B., Megraud F. et al. In vitro Anti-Helicobacter pylori Activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics // Antimicrob. Agents Chemother. 2001; 45: 3156-3161. 10.1128/AAC.45.11.3156-3161.2001

94. Prokesova L., Novakova M., Julak J., Mara M. Effect of Bacillus firmus and other sporulating aerobic microorganisms on in vitro stimulation of human lymphocytes. A comparative study // Folia Microbiol. 1994; 39: 501-504. 10.1007/BF02814071

95. Ramarao N., Lereclus D. Adhesion and cytotoxicity of Bacillus cereus and Bacillus thuringiensis to epithelial cells are FlhA and PlcR dependent, respectively // Microbes Infect. 2006; 8: 1483-1491. 10.1016/j.micinf.2006.01.005

96. Ranji P., Akbarzadeh A., Rahmati-Yamchi M. Associations of probiotics with vitamin D and leptin receptors and their effects on colon cancer // Asian Pac. J. Cancer Prev. 2015; 16: 3621-3627. 10.7314/APJCP.2015

97. Rao K.P., Chennappa G., Suraj U., Nagaraja H., Raj A.C., Sreenivasa M.Y. Probiotic potential of Lactobacillus strains isolated from sorghum-based traditional fermented food // Probiotics Antimicrob. Proteins. 2015; 7: 146-156. 10.1007/s12602-015-9186-6

98. Redman M.G., Ward E.J., Phillips R.S. The efficacy and safety of probiotics in people with cancer: a systematic review // Ann. Oncol. 2014; 25: 1919-1929. 10.1093/annonc/mdu106

99. Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M. et al. Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species // Genome Biol. 2004; 5: 77. 10.1186/gb-2004-5-10-r77

100. Riazi S., Wirawan R.E., Badmaev V., Chikindas M.L. Characterization of lactosporin, a novel antimicrobial protein produced by Bacillus coagulans ATCC 7050 // J. Appl. Microbiol. 2009; 106: 1370-1377.

101. Ripert G., Racedo S.M., Elie A.M., Jacquot C., Bressollier P., Urdaci M.C. Secreted compounds of the probiotic Bacillus clausii strain O/C inhibit the cytotoxic effects induced by Clostridium difficile and Bacillus cereus toxins // Antimicrob. Agents Chemother. 2016; 60: 3445-3454. 10.1128/AAC.02815-15

102. Rowan N.J., Deans K., Anderson J.G., Gemmell C.G., Hunter I.S., Chaithong T. Putative virulence factor expression by clinical and food isolates of Bacillus spp. after growth in reconstituted infant milk formulae // Appl. Environ. Microbiol. 2001; 67: 3873-3881. 10.1128/AEM.67.9.3873-3881.2001

103. Sanchez B., Arias S., Chaignepain S., Denayrolles M., Schmitter J.M., Bressollier P. et al. Identification of surface proteins involved in the adhesion of a probiotic Bacillus cereus strain to mucin and fibronectin // Microbiology. 2009; 155. 1708-1716. 10.1099/mic.0.025288-0

104. SCAN (1999). Opinion of of the Scientific Steering Committee on Antimicrobial Resistance. European Commission, Health and Consumer Protection Directorate-General. (SCAN) Scientific Committee on Animal Nutrition. Available at: https://ec.europa.eu/food/sites/food/files/safety/docs/sci-com_ssc_out50_en.pdf

105. SCAN (2002). Opinion of the Scientific Committee on Animal Nutrition (SCAN) on the use of Bacillus licheniformis NCTC 13123 in Feeding Stuffs for Pigs (product AlCare). European Commission, Health and Consumer Protection Directorate-General. (SCAN) Scientific Committee on Animal Nutrition. Available at: https://ec.europa.eu/food/sites/food/files/safety/docs/animal-feed_additives_rules_scan-old_report_out79.pdf

106. SCAN (2003). Opinion of the Scientific Committee on Animal Nutrition, on the Criteria for Assessing the Safety of Microorganisms Resistant to Antibiotics of Human Clinical and Veterinary Importance. European Commission, Health and Consumer Protection Directorate-General. (SCAN) Scientific Committee on Animal Nutrition. Available at: https://www.efsa.europa.eu/en/efsajournal/pub/223

107. Scott K.P., Antoine J.M., Midtvedt T., van Hemert S. Manipulating the gut microbiota to maintain health and treat disease // Microb. Ecol. Health Dis. 2015; 26: 25877 10.3402/mehd.v26.25877

108. Shida K., Nomoto K. Probiotics as efficient immuno potentiators: translational role in cancer prevention // Indian J. Med. Res. 2013; 138: 808-814.

109. Shimizu K., Ogura H., Asahara T., Nomoto K., Morotomi M., Tasaki O. et al. Probiotic/synbiotic therapy for treating critically ill patients from a gut microbiota perspective // Dig. Dis. Sci. 2013; 58: 23-32. 10.1007/s10620-012-2334

110. Shobharani P., Padmaja R.J., Halami P.M. Diversity in the antibacterial potential of probiotic cultures Bacillus licheniformis MCC2514 and Bacillus licheniformis MCC2512 // Res. Microbiol. 2015; 166: 546-554. 10.1016/j.resmic.2015.06.003

111. Sorokulova I.B., Pinchuk I.V., Denayrolles M., Osipova I.G., Huang J.M., Cutting S. et al. The safety of two Bacillus probiotic strains for human use // Dig. Dis. Sci. 2008; 53: 954-963. 10.1007/s10620-007-9959-1

112. Smirnov V.V., Reznik S.R., V’iunitskaia V.A. et al. The effect of the complex probiotic Sporolact on the intestinal microbiocenosis of warm-blooded animals // Mikrobiol. Z. 1995; 57: 42-49.

113. Sudha R.M., Bhonagiri S. Efficacy of Bacillus coagulans strain Unique IS-2 in the treatment of patients with acute diarrhea // Int. J. Probiotics Prebiotics. 2012; 7: 33-37.

114. Takano H. The regulatory mechanism underlying light-inducible production of carotenoids in non phototrophic bacteria // Biosci. Biotechnol. Biochem. 2016; 80: 1264-1273. 10.1080/09168451.2016.1156478

115. Tam N.K., Uyen N.Q., Hong H.A., Duc L.H., Hoa T.T., Serra C.R. et al. The intestinal life cycle of Bacillus subtilis and close relatives // J. Bacteriol. 2006; 188: 2692-2700. 10.1128/JB.188.7.2692-2700.2006

116. Tamang J.P., Watanabe K., Holzapfel W.H. Review: diversity of microorganisms in global fermented foods and beverages // Front. Microbiol. 2016; 7: 377 10.3389/fmicb.2016.00377

117. Tanaka K., Takanaka S., Yoshida K.I. A second-generation Bacillus cell factory for rare inositol production // Bioengineered. 2014; 5: 331-334. 10.4161/bioe.29897

118. Terlabie N.N., Sakyi-Dawson E., Amoa-Awua W.K. The comparative ability of four isolates of Bacillus subtilis to ferment soybeans into dawadawa // Int. J. Food Microbiol. 2006; 106: 145-152. 10.1016/j.ijfoodmicro.2005.05.021

119. Tewari V.V., Dubey S.K., Gupta G. Bacillus clausii for prevention of late-onset sepsis in preterm infants: a randomized controlled trial // J. Trop. Pediatr. 2015; 61: 377-385. 10.1093/tropej/fmv050.

120. Thakur N., Rokana N., Panwar H. Probiotics: selection criteria, safety and role in health and disease // J. Innov. Biol. 2016; 3: 259-270.

121. Trocino A., Xiccato G., Carraro L., Jimenez G. Effect of diet supplementation with Toyocerin® (Bacillus cereus var. toyoi) on performance and health of growing rabbits // World Rabbit Sci. 2005; 13: 17-28.

122. Urgesi R., Casale C., Pistelli R., Rapaccini G.L., De Vitis I. A randomized double-blind placebo-controlled clinical trial on efficacy and safety of association of simethicone and Bacillus coagulans (Colinox®) in patients with irritable bowel syndrome // Eur. Rev. Med. Pharmacol. Sci. 2014; 18: 1344-1353.

123. Voichishina L.G., Chaplinskii V., V’iunitskaia V.A. The use of sporulating bacteria in treating patients with dysbacteriosis // Vrach. Delo. 1991; 12: 73-75.

124. Von Mollendorff J.W., Vaz-Velho M., Todorov S.D. Boza, a traditional cereal-based fermented beverage: a rich source of probiotics and bacteriocin-producing lactic acid bacteria // Functional Properties of Traditional Foods / Ed. by Kristbergsson K., Ötles S. — Boston, MA: Springer, 2016. — Р. 157-188.

125. Wang J., Tang H., Zhang C., Zhao Y., Derrien M., Rocher E. et al. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice // ISME J. 2015; 9: 1-15. 10.1038/ismej.2014.99

126. Weese J.S., Martin H. Assessment of commercial probiotic bacterial contents and label accuracy // Can. Vet. J. 2011; 52: 43.

127. Wu T., Zhang Y., Lv Y., Li P., Yi D., Wang L., Zhao D., Chen H., Gong J., Hou Y. Beneficial Impact and Molecular Mechanism of Bacillus coagulans on Piglets' Intestine // Int. J. Mol. Sci. 2018; 19 (7).

128. Xu D., Cote J.C. Phylogenetic relationships between Bacillus species and related genera inferred from comparison of 3 end 16S rDNA and 5 end 16S-23S ITS nucleotide sequences // Int. J. Syst. Evol. Microbiol. 2003; 53: 695-704. 10.1099/ijs.0.02346-0

129. Yang H.J., Kwon D.Y., Kim H.J., Kim M.J., Jung D.Y., Kang H.J. et al. Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer’s type dementia // Eur. J. Nutr. 2014; 5477-88. 10.1007/s00394-014-0687-y

130. Yang O.O., Kelesidis T., Cordova R., Khanlou H. Immunomodulation of antiretroviral drug-suppressed chronic HIV-1 infection in an oral probiotic double-blind placebo-controlled trial // AIDS Res. Hum. Retroviruses. 2014; 30: 988-995. 10.1089/aid.2014.0181

131. Zhang H.L., Li W.S., Xu D.N., Zheng W.W., Liu Y., Chen J. et al. Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice // Exp. Ther. Med. 2016; 12: 2554-2562. 10.3892/etm.2016.3686

132. Zhao C., Lv X., Fu J., He C., Hua H., Yan Z. In vitro inhibitory activity of probiotic products against oral Candida species // J. Appl. Microbiol. 2016; 121: 254-262. 10.1111/jam.13138

133. Zheng L.P., Zou T., Ma Y.J., Wang J.W., Zhang Y.Q. Antioxidant and DNA damage arotecting Activity of exopolysaccharides from the endophytic bacterium Bacillus Cereus SZ1 // Molecules. 2016; 21: 174 10.3390/molecules21020174

134. Zouari R., Abdallah-Kolsi R.B., Hamden K., Feki A.E., Chaabouni K., Makni-Ayadi F. et al. Assessment of the antidiabetic and antilipidemic properties of Bacillus subtilis SPB1 biosurfactant in alloxan-induced diabetic rats // Pept. Sci. 2015; 104: 764-774. 10.1002/bip.22705

135. Мечников И.И. Этюды оптимизма. — Новосибирск: Наука, 1988. — 244 с.

136. Харченко Н.В. Вивчення ефективності препарату Лактовіт Форте при хронічних хворобах шлунково-кишкового тракту із синдромом дисбактеріозу кишечника // Сучасна гастроентерологія. — 2007. — № 3(35). — С. 53-56.

137. Квашнина Л., Радионов В., Матвиенко И.Н. Возможности коррекции дефицита железа и нарушений микробиоценоза кишечника у детей // Клінічна педіатрія. — 2016. — № 6(74). — 10-17.

138. Квашніна Л., Радіонов В. Корекція дисбіоза кишечника у процесі реабілітації дітей молодшого шкільного віку після інфекційних гастроентероколітів // Клінічна педіатрія. — 2012. — № 7(42). — С. 134-138.

139. Подольский Вл., Подольский В. Лікування змін мікробіоценозу урогенітальних органів у жінок з порушеннями вегетативного гомеостазу та змінами репродуктивного здоров’я // Здоровье женщины. — 2015. — № 10(106). — С. 125-128.

140. https://www.ncbi.nlm.nih.gov/genome

141. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223449/

142. www.fda.gov/grasnoticeinventor

143. www.who.int


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