Журнал "Здоров`я дитини" Том 18, №3, 2023
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Значення вітаміну D у перебігу SARS-CoV-2-інфекції та long COVID у дітей (огляд літератури)
Автори: Волянська Л.А., Бурбела Е.І., Косовська Т.М., Перестюк В.О., Боярчук О.Р.
Тернопільський національний медичний університет імені І.Я. Горбачевського МОЗ України, м. Тернопіль, Україна
Рубрики: Педіатрія/Неонатологія
Розділи: Довідник фахівця
Версія для друку
Тривале спостереження за пандемією SARS-CoV-2 у дитячій популяції виявило наявність стійких симптомів з частотою від 1 : 4 до 1 : 10 через 4 і більше тижні після початку цієї інфекції. Питання про роль вітаміну D у перебігу COVID-19 і розвитку тривалого порушення стану здоров’я досі залишається дискусійним. Мета даного огляду — узагальнення й уточнення впливу вітаміну D на перебіг COVID-19 і постковідного періоду в дітей. Був проведений електронний пошук наукових досліджень у відомих базах даних PubMed, Scopus, ResearchGate, Wiley Online Library і Google Scholar з 2019 по лютий 2023 р. Аналіз досліджень COVID-19, постковідного періоду і впливу гіповітамінозу D на їх перебіг засвідчує неоднозначність оприлюднених результатів у педіатричній когорті. Низка дослідників пов’язали дефіцит вітаміну D з вищою смертністю, вищими показниками госпіталізації та більшою тривалістю останньої. Гіповітаміноз D погіршує функціонування імунної системи в інфікованому пандемічним коронавірусом організмі, що збільшує ризики тяжкого перебігу хвороби і смерті. Але ця гіпотеза ще потребує поглибленого вивчення для розуміння суті впливу вітаміну D на перебіг коронавірусної інфекції та long COVID. Гіпотеза про взаємозв’язок між гіповітамінозом D та імуносупресією при інфікуванні пандемічним корнавірусом і його потенційна роль у формуванні тривалих порушень стану здоров’я після гострого COVID-19 ще перебувають у стадії перманентного вивчення.
Long-term observation of the SARS-CoV-2 pandemic in the pediatric population revealed the presence of persistent symptoms in 1 : 4 to 1 : 10 children four or more weeks after the onset of this infection. The question about the role of vitamin D in the course of COVID-19 and the development of long-term health conditions is still debatable. The purpose of this review is to generalize and clarify the effect of vitamin D on the course of COVID-19 and the post-COVID period in children. Electronic search for scientific publications was done in the PubMed, Scopus, ResearchGate, Wiley Online Library and Google Scholar databases from 2019 to February 2023. Analysis of studies on COVID-19, the post-COVID period, and the impact of hypovitaminosis D on their course attests to the ambiguity of published results in the pediatric cohort. A number of researchers have linked vitamin D deficiency to higher mortality, higher hospitalization rates, and longer hospital stays. Hypovitaminosis D impairs the functioning of the immune system in an organism infected with the pandemic coronavirus, which increases the risk of severe course and mortality. But this hypothesis still needs in-depth study to understand the essence of the effect of vitamin D supplementation on the course of the coronavirus infection and long COVID. The hypothesis about the relationship between hypovitaminosis D and immunosuppression during infection with a pandemic coronavirus and its potential role in the formation of long-term health conditions after acute COVID-19 is still under permanent study.
COVID-19; long COVID; SARS-CoV-2; вітамін D; діти
COVID-19; long COVID; SARS-CoV-2; vitamin D; children
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