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"Child`s Health" Том 13, №1, 2018

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Development of the immune response in pneumonia due to Staphylococcus aureus (part 8)

Authors: Абатуров А.Е., Никулина А.А.
ГУ «Днепропетровская медицинская академия МЗ Украины», г. Днепр, Украина

Categories: Pediatrics/Neonatology

Sections: Specialist manual

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Summary

У статті на підставі літературних джерел продемонстрована роль клітинних реакцій у розвитку імунної відповіді при пневмонії, викликаній Staphylococcus aureus. Описано механізми взаємодії Staphylococcus aureus з Т-клітинами адаптивної імунної системи, В-лімфоцитами. Подано порівняльну характеристику активації Т-клітин конвенціональним антигеном і суперантигеном бактерій Staphylococcus aureus, описані спадкові захворювання з порушеннями Тh17-асоційованого сигнального шляху, пов’язані з ризиком розвитку стафілококової інфекції. Продемонстровано основні механізми бактеріального кілингу імуноцитів.

В статье на основании литературных источников продемонстрирована роль клеточных реакций в развитии иммунного ответа при пневмонии, вызванной Staphylococcus aureus. Описаны механизмы взаимодействия Staphylococcus aureus с Т-клетками адаптивной иммунной системы, В-лимфоцитами. Дана сравнительная характеристика активации Т-клеток конвенциональным антигеном и суперантигеном бактерий Staphylococcus aureus, описаны наследственные заболевания с нарушениями Тh17-ассоциированного сигнального пути, связанные с риском развития стафилококковой инфекции. Продемонстрированы основные механизмы бактериального киллинга иммуноцитами.

In the article, based on the literature, the role of cellular responses in the development of the immune response in pneumonia caused by Staphylococcus aureus is demonstrated. The mechanisms of interaction of Staphylococcus aureus with T-cells of the adaptive immune system, B-lymphocytes are described. A comparative characteristic of T-cell activation by the conventional antigen and superantigen of Staphylococcus aureus bacteria is presented, hereditary diseases with disorders of the Th17-associated signaling pathway associated with the risk of developing staphylococcal infection are described. The basic mechanisms of bacterial killing by immunocytes are de­monstrated.


Keywords

пневмонія; імунна відповідь; Staphylococcus aureus; Т-лімфоцити; В-лімфоцити

пневмония; иммунный ответ; Staphylococcus aureus; Т-лимфоциты; В-лимфоциты

pneumonia; immune response; Staphylococcus aureus; T-lymphocytes; B-lymphocytes


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